Does cymbalta make you sleepy?

Last Update: April 20, 2022

This is a question our experts keep getting from time to time. Now, we have got the complete detailed explanation and answer for everyone, who is interested!

Asked by: Reed Hickle
Score: 4.6/5 (41 votes)

The serotonin-norepinephrine reuptake inhibitors (SNRIs) are similar medications used to treat depression, anxiety, and sometimes, chronic pain. They include duloxetine (Cymbalta) and venlafaxine (Effexor) and can also cause drowsiness and fatigue.

Should I take Cymbalta morning or night?

Can I take Cymbalta (duloxetine) at night? It is best to take Cymbalta (duloxetine) at the same time every day. Most people take it in the morning, but if you find that you feel drowsy after taking it in the morning, try taking it in the evening.

Does drowsiness from Cymbalta go away?

Duloxetine normally takes 2 to 4 weeks to work. It may take longer if you're taking it for nerve pain. Common side effects include feeling sick, a dry mouth, headache, constipation and feeling sleepy. These side effects are usually mild and go away after a couple of weeks.

Is sleepiness a side effect of Cymbalta?

Nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweating may occur. If any of these effects persist or worsen, tell your doctor promptly. Dizziness or lightheadedness may occur, especially when you first start or increase your dose of this drug.

Does Cymbalta help with sleep?

Compared with placebo, duloxetine treatment was associated with a positive, but negligible, benefit on clinical ratings of insomnia and with more frequent sleep-related TEAEs that did not negatively impact overall efficacy for major depressive disorder.

Cymbalta (Duloxetine): What are the Side Effects? Watch Before You Start!

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Why is Cymbalta bad for you?

Hyponatremia can cause headaches, confusion, weakness, and in severe cases can lead to fainting, seizures, coma, and death. Some patients taking Cymbalta have developed liver problems. In rare cases, this has lead to liver failure and death.

Will Cymbalta give me energy?

How Long Does It Take For Duloxetine To Work? Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.

Can I drink coffee with Cymbalta?

If you drink a lot of coffee, cola drinks or other caffeine drinks when taking duloxetine, it can put you at a higher risk of getting serotonin syndrome. The symptoms are any combination of the following: high fever. agitation.

What is the most common side effect of Cymbalta?

The most commonly observed adverse reactions in CYMBALTA-treated patients (as defined above) were: Diabetic Peripheral Neuropathic Pain: nausea, somnolence, decreased appetite, constipation, hyperhidrosis, and dry mouth.

Can I start Cymbalta at 60 mg?

Adults—At first, 60 milligrams (mg) once a day. Some patients may start at 30 mg once a day for 1 week before increasing the dose to 60 mg once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 120 mg per day.

Is 90 mg of duloxetine a lot?

Results from this study suggest that rapid dose escalation of duloxetine (60 mg/day --> 90 mg/day --> 120 mg/day) is safe and tolerable. Despite weekly escalation, the majority of adverse events were mild and transient and occurred in the first week of duloxetine dosing (at 60 mg once daily).

Can Cymbalta help you lose weight?

As with the 2006 analysis, the researchers found that in the short-term, those taking Cymbalta experienced modest weight loss, on average, compared with those taking placebo. In the longer-term, Cymbalta caused modest weight loss in some trials but modest weight gain in others.

Does Duloxetine cause brain fog?

Short-Term Memory Loss and Brain Fog

A lack of short-term memory, difficulty in concentrating, and brain zaps are just some of the complaints experienced by people taking Cymbalta.

How good is Cymbalta?

Cymbalta has an average rating of 6.3 out of 10 from a total of 541 ratings for the treatment of Depression. 52% of reviewers reported a positive effect, while 29% reported a negative effect.

How does Cymbalta make you feel?

Drowsiness, insomnia, nausea, a headache, dry mouth, constipation, and dizziness. Most people experience side effects with Cymbalta and one in six people stop taking the drug because of them. Severe skin reactions and urinary retention have also been reported with Cymbalta.

Is Cymbalta anti inflammatory?

The anti-inflammatory activity of duloxetine, a serotonin/norepinephrine reuptake inhibitor, prevents kainic acid-induced hippocampal neuronal death in mice. J Neurol Sci. 2015 Nov 15;358(1-2):390-7.

How does Cymbalta work for back pain?

Treating the emotional side of pain is one way Cymbalta helps people with chronic pain. Cymbalta belongs to a class of anti-depressants known as serotonin and norepinephrine reuptake inhibitors (SNRIs). SNRIs boost serotonin and norepinephrine levels by stopping their reuptake (re-absorption) into brain cells.

How effective is Cymbalta for nerve pain?

Duloxetine at 60 mg daily is effective in treating painful diabetic peripheral neuropathy in the short-term to 12 weeks with a risk ratio (RR) for 50% pain reduction at 12 weeks of 1.65 (95% confidence interval (CI) 1.34 to 2.03), number needed to treat (NNT) 6 (95% CI 5 to 10).

Does Cymbalta make you feel worse before better?

Some patients may feel worse instead of better when first starting drugs like Cymbalta or when changing the dose. You may feel more anxious, agitated, hostile, aggressive, impulsive, and feel like you are not yourself or become less inhibited. You may have thoughts of suicide, hurting yourself or other people.

Is Cymbalta a mood stabilizer?

As an SNRI, duloxetine inhibits the reuptake of the neurotransmitters serotonin and norepinephrine in the central nervous system and as a result, increasing the amounts available in the brain. These brain chemicals work to help regulate mood, so increasing their levels can help relieve symptoms of depression.

Can Cymbalta help with anxiety?

Cymbalta can restore balance by preventing your brain cells from quickly absorbing these neurotransmitters. By bringing equilibrium back to the chemicals in your brain, Cymbalta can help alleviate anxiety, lessen panic attacks, and improve your mood.

What does Cymbalta do to the brain?

How Does Cymbalta Work? Cymbalta inhibits the reuptake of serotonin and norepinephrine in the central nervous system. It also increases dopamine by acting on dopamine reuptake pumps, thus increasing the diffusion of dopamine in the brain.

Who should not take duloxetine?

You should not use this medicine if you have had an allergic reaction to duloxetine, or if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days. You should not use this medicine if you have uncontrolled narrow-angle glaucoma.

Which is better Cymbalta or Wellbutrin?

Wellbutrin (Bupropion) Improves mood and relieves certain types of pain. Cymbalta (duloxetine) is good for treating depression, anxiety, and some forms of chronic pain, but it is more likely than other antidepressants to cause problems if you drink alcohol or have high blood pressure.

What works better than Cymbalta?

What is a good alternative to Cymbalta? Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). Other SNRIs include Effexor (venlafaxine), Pristiq (desvenlafaxine), and Savella (milnacipran).