During breakdown of hemoglobin the bilirubin is formed from?

Last Update: April 20, 2022

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Asked by: Prof. Eddie Greenfelder PhD
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Formation of Bilirubin
Roughly, 80% of bilirubin is made from the breakdown of hemoglobin in senescent red blood cells, and prematurely destroyed erythroid cells in the bone marrow. The remainder originates from the turnover of various heme-containing proteins found in other tissues, primarily the liver and muscles.

What is the bilirubin formed from?

Bilirubin is a brownish yellow substance found in bile. It is produced when the liver breaks down old red blood cells. Bilirubin is then removed from the body through the stool (feces) and gives stool its normal color.

Where is hemoglobin broken down into bilirubin?

Bilirubin, a brownish yellow pigment of bile, secreted by the liver in vertebrates, which gives to solid waste products (feces) their characteristic colour. It is produced in bone marrow cells and in the liver as the end product of red-blood-cell (hemoglobin) breakdown.

What converts heme to bilirubin?

Senescent erythrocytes are phagocytosed and degraded largely by macrophages present in the spleen and liver. Within these cells, Heme is first converted to bilirubin in a two-step enzymatic process which employs "Biliverdin" as an intermediate. ... The macrophages then excrete the resultant bilirubin into the plasma.

How conjugated bilirubin is formed?

In the bloodstream, unconjugated bilirubin binds to albumin to facilitate its transport to the liver. Once in the liver, glucuronic acid is added to unconjugated bilirubin by the enzyme glucuronyl transferase. This forms conjugated bilirubin, which is soluble.

Bilirubin Metabolism Simplified

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