How is tuberculosis meningitis diagnosed?

Last Update: April 20, 2022

This is a question our experts keep getting from time to time. Now, we have got the complete detailed explanation and answer for everyone, who is interested!

Asked by: Wendy Beahan DDS
Score: 4.5/5 (49 votes)

Diagnosis of TB meningitis is made by analysing cerebrospinal fluid collected by lumbar puncture. When collecting CSF for suspected TB meningitis, a minimum of 1ml of fluid should be taken (preferably 5 to 10ml). The CSF usually has a high protein, low glucose and a raised number of lymphocytes.

How is TB meningitis diagnosed?

Other tests that may be done include:
  1. Biopsy of the brain or meninges (rare)
  2. Blood culture.
  3. Chest x-ray.
  4. CSF examination for cell count, glucose, and protein.
  5. CT scan of the head.
  6. Gram stain, other special stains, and culture of CSF.
  7. Polymerase chain reaction (PCR) of CSF.
  8. Skin test for TB (PPD)

What are the signs and symptoms of TB meningitis?

Tuberculous Meningitis involves the central nervous system. Headaches and behavioral changes may be noticed initially. Fever, headache, a stiff neck, and vomiting may also occur. Symptoms among older children and adults may progress from irritability to confusion, drowsiness, and stupor, possibly leading to coma.

Is TB meningitis commonly fatal?

Sometimes, the bacteria will travel to the meninges, which are the membranes surrounding the brain and spinal cord. Infected meninges can result in a life-threatening condition known as meningeal tuberculosis.

What are the stages of TB meningitis?

TB meningitis is often described in three stages, but patients don't necessarily progress from one stage to the next in an orderly fashion. Stage 1 is considered alert, stage 2 is lethargy, and stage 3 is coma.

Guy Thwaites: Tuberculous meningitis

28 related questions found

Is TB in brain curable?

It is curable in most cases.

How do u know if u have meningitis?

Meningitis and septicaemia can kill in hours - know the symptoms. The first symptoms are usually fever, vomiting, headache and feeling unwell. Limb pain, pale skin, and cold hands and feet often appear earlier than the rash, neck stiffness, dislike of bright lights and confusion.

How do you catch bacterial meningitis?

Common bacteria or viruses that can cause meningitis can spread through coughing, sneezing, kissing, or sharing eating utensils, a toothbrush or a cigarette. These steps can help prevent meningitis: Wash your hands.

Which medicine can fight viral meningitis?

Commonly used meningitis treatments include a class of antibiotics called cephalosporins, especially Claforan (cefotaxime) and Rocephin (ceftriaxone). Various penicillin-type antibiotics, aminoglycoside drugs such as gentamicin, and others, are also used.

What is hydrocephalus in tuberculous meningitis?

The exact pathogenesis of hydrocephalus in tuberculous meningitis is unclear. The hydrocephalus is probably a result of basal adhesive meningeal reaction wherein the flow of the CSF is obliterated in its course from the point of exit from the fourth ventricle to the site of its absorption in the arach- noid villi.

Does tuberculosis affect the brain?

Tuberculosis (TB) is a multi-systemic infectious disease caused by different species of mycobacteria, usually Mycobacterium tuberculosis in humans (1). Tuberculosis of the nervous system can attack the meninges, brain, spinal cord, cranial and peripheral nerves, ears, and eyes.

How long will it take to recover from meningitis?

Most people who get mild viral meningitis usually recover completely in 7 to 10 days without treatment. Antiviral medicine may help people with meningitis caused by viruses such as herpesvirus and influenza. Antibiotics do not help viral infections, so they are not useful in the treatment of viral meningitis.

WHO TB meningitis treatment?

An effective treatment regimen recommended by the World Health Organization (WHO) consists of isoniazid, rifampicin, and pyrazinamide, usually with a fourth drug such as ethambutol or streptomycin, as first-line anti-tuberculosis drugs in patients with tuberculous meningitis [9, 10].

What are the 3 types of tuberculosis?

Tuberculosis: Types
  • Active TB Disease. Active TB is an illness in which the TB bacteria are rapidly multiplying and invading different organs of the body. ...
  • Miliary TB. Miliary TB is a rare form of active disease that occurs when TB bacteria find their way into the bloodstream. ...
  • Latent TB Infection.

Is bacterial meningitis curable?

Can bacterial meningitis be cured? There is a 10 percent death rate from bacterial meningitis, but if diagnosed and treated early enough, most people recover.

Is surgery required for brain TB?

The two main manifestations of brain tuberculosis that require surgery are hydrocephalus associated with tuberculous meningitis (TBMH) and brain tuberculomas. TBMH most often responds to medical therapy but surgery is required promptly for those who fail medical therapy.

Does TB cause memory loss?

There are a number of causes of memory loss, including medications; heavy drinking; stress; depression; head injury; infections such as HIV, tuberculosis, syphilis and herpes; thyroid problems; lack of quality sleep; and low levels of vitamins B1 and B12.

Can Brain TB cause death?

Brain abscesses of Mycobacterium tuberculosis can induce seizures and coma leading to death and complicated due to multiorgan failure. Rapid diagnosis and early intervention is vital for successful outcome for patients.

What virus can cause meningitis?

Several different viruses and bacteria can cause meningitis, including:
  • meningococcal bacteria – there are several different types, called A, B, C, W, X, Y and Z.
  • pneumococcal bacteria.
  • Haemophilus influenzae type b (Hib) bacteria.
  • enteroviruses – viruses that usually only cause a mild stomach infection.
  • the mumps virus.

What does a meningitis headache feel like?

A headache caused by meningitis is typically described as severe and unrelenting. It does not subside by taking an aspirin. Stiff neck. This symptom most commonly involves a reduced ability to flex the neck forward, also called nuchal rigidity.

What is the survival rate for bacterial meningitis?

Prognosis of meningitis depends on the cause. Untreated bacterial meningitis has a very high death rate. Even with appropriate treatment, the death rate from bacterial meningitis is about 15-20%, with a higher death rate associated with increasing age.

What are 6 symptoms of meningitis?

Common signs and symptoms of meningitis and septicaemia
  • Fever with cold hands and feet.
  • Vomiting.
  • Drowsy or difficult to wake.
  • Confusion and irritability.
  • Severe muscle pain.
  • Pale blotchy skin, spots or rash (See Glass Test (link))
  • Severe headache.
  • Stiff neck.

Can a CT scan detect meningitis?

The CT scan is a valuable tool in diagnosing meningitis. The contrast dye that is injected during the test can highlight brain, skull, and sinus inflammation- all complications and signs of meningitis.

Can CBC detect meningitis?

Meningitis blood tests

A complete blood count (CBC) or total protein count check for heightened levels of certain cells and proteins that can suggest a meningitis infection. A procalcitonin blood test can also help your doctor tell if an infection is more likely caused by either bacteria or a virus.