What dermatological issue is linked to amiodarone use?

Last Update: April 20, 2022

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Asked by: Mr. Trever Pfannerstill Sr.
Score: 4.1/5 (46 votes)

The amiodarone molecule contains a large amount of inorganic iodine, which may exacerbate certain skin diseases, such as dermatitis herpetiformis and psoriasis.

Does amiodarone affect the skin?

Conclusion: Skin side effects are common, they usually occur as photosensitivity, more rarely as a slate-grey discoloration of the skin. Amiodarone induced slate-grey pigmentation is commonly observed in unprotected light exposed skin. Its incidence ranges from 2-57%.

Can amiodarone cause rashes?

Amiodarone can cause a red rash which resembles a bad sunburn, and this rash can be triggered with prolonged sun exposure. After several years of exposure, amiodarone can cause a bluish discoloration of the skin. Many drugs interact with amiodarone.

How does amiodarone affect the eyes?

Amiodarone use is associated with the development of ocular adverse effects including optic neuropathy (which occurs rarely) and corneal deposits (which occur in most patients). All patients experiencing new or worsening visual symptoms whilst taking amiodarone should be referred for ophthalmological assessment.

Which of the following adverse effects may occur due to a dihydropyridine?

Dihydropyridine CCBs can cause flushing, headache, excessive hypotension, edema and reflex tachycardia.

Amiodarone Mechanism of Action / How Amiodarone works / Amiodarone pharmacology and side effects

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What is the use of dihydropyridine?

Dihydropyridine calcium channel blockers are drugs used to treat high blood pressure and severe angina (chest pain caused by lack of oxygen to the heart muscle). Dihydropyridines are one of the different types of calcium channel blockers; they predominately act on blood vessels with less effect on the heart.

What is the difference between dihydropyridine and Nondihydropyridine?

Dihydropyridine (DHP) CCBs tend to be more potent vasodilators than non-dihydropyridine (non-DHP) agents, whereas the latter have more marked negative inotropic effects.

What can be used instead of amiodarone?

Dronedarone has been viewed as a potential therapeutic alternative for amiodarone because of a lower risk for pulmonary, thyroid, and dermatologic adverse effects. Compared with amiodarone, dronedarone has poor bioavailability and a shorter terminal disposition half-life, which dictates a twice-daily dosing regimen.

How long can a person take amiodarone?

Never stop taking it without consulting your doctor.

This medication must be taken regularly for one to three weeks before a response is seen and for several months before the full effect occurs. Due to the drug's long half-life, it will remain in your body for up to two months.

Why is amiodarone bad for you?

This medication has the risk of serious side effects. These include serious lung problems, liver problems, and a worsening of your irregular heart rate. These problems can be fatal. If you need to be treated with amiodarone for an irregular heart rate, you'll need to be admitted into the hospital to get the first dose.

Can amiodarone be stopped suddenly?

Do not stop taking amiodarone without talking to your doctor. You may need to be closely monitored or even hospitalized when you stop taking amiodarone. Amiodarone may remain in your body for some time after you stop taking it, so your doctor will watch you carefully during this time.

What are the long term side effects of amiodarone?

Amiodarone has been associated with multiple systemic adverse effects, including bradycardia, hypothyroidism or hyperthyroidism, pulmonary toxicity, ocular deposits, and liver function derangements.

What is the safest antiarrhythmic drug?

Of all antiarrhythmic agents, dofetilide and amiodarone have been proven safe in patients with heart failure.

Why does amiodarone cause blue skin?

Finally, the presence of amiodarone deposits in the skin, with or without lipofuscin, is able to induce the blue-gray hyperpigmentation. This pigmentation could be explained by the Tyndall effect, in which dermal pigment, whether melanin, iron, or other pigment, is perceived as blue, gray, or blue-gray.

What are the symptoms of amiodarone toxicity?

The clinical presentation of amiodarone pulmonary toxicity is very nonspecific. Common symptoms are shortness of breath, dry cough, fever, respiratory distress, and fatigue; sometimes it can mimic acute respiratory distress syndrome.

Can amiodarone cause hypothyroidism?

Amiodarone can lead to both hypothyroidism (amiodarone-induced hypothyroidism) and less commonly hyperthyroidism (amiodarone-induced thyrotoxicosis) and relates to high iodine content within the molecule as well as to several unique intrinsic properties of amiodarone.

Is amiodarone hard on the kidneys?

Amiodarone is a class III antiarrhythmic drug highly effective against a wide spectrum of ventricular tachyarrhythmias. We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone.

What should be avoided when taking amiodarone?

amiodarone food

You should avoid consuming grapefruits and grapefruit juice while taking amiodarone. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Grapefruit can raise the levels of amiodarone in your body and lead to dangerous side effects.

What does amiodarone do to your lungs?

Amiodarone may induce the production of toxic O2 radicals, which can directly damage cells (9). It also appears to promote the accumulation of phospholipids in tissues (9). Typically, the lungs of patients with APT show a diffuse interstitial pneumonitis on microscopic inspection (Figure 1).

Is amiodarone still used?

Amiodarone has been used both in the treatment of acute life-threatening arrhythmias as well as the long term suppression of arrhythmias. It is used both in supraventricular arrhythmias and ventricular arrhythmias.

What is the drug of choice for atrial fibrillation?

Beta blockers and calcium channel blockers are the drugs of choice because they provide rapid rate control. 4,7,12 These drugs are effective in reducing the heart rate at rest and during exercise in patients with atrial fibrillation.

Is amiodarone a good drug?

Several studies have shown that amiodarone is superior to other antiarrhythmic drugs in the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation.

Can you use dihydropyridine and Nondihydropyridine?

EVIDENCE-BASED ANSWER. Probably. Dual calcium channel blocker (CCB) therapy with a dihydropyridine and nondihydropyridine leads to a 10 to 12 mmHg greater reduction in systolic blood pressure and a 5 mmHg greater reduction in diastolic pressure over monotherapy.

Is Magnesium a natural calcium channel blocker?

Oral magnesium acts as a natural calcium channel blocker, increases nitric oxide, improves endothelial dysfunction, and induces direct and indirect vasodilation.

Is calcium channel blocker a vasodilator?

Because muscle contraction is largely dependent upon influx of calcium, its inhibition causes relaxation, particularly in arterial beds. Thus, the major effects of the calcium channel blockers are relaxation of vascular and arterial smooth muscle cells resulting in arterial vasodilation.