What is cytostatic action?

Last Update: April 20, 2022

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Asked by: Prof. Ronny Welch III
Score: 4.5/5 (25 votes)

Cytostatic (or chemotherapeutic) agents (cytostatics) are plant-derived or synthetic substances that can cause death or inhibit growth and dividing of a cell. Cytostatics achieve these growth-inhibiting effects by specific mechanisms of action, which, in one way or another, affect the cells' metabolism.

What is a cytostatic effect?

(SY-toh-STA-tik AY-jent) A substance that slows or stops the growth of cells, including cancer cells, without killing them. These agents may cause tumors to stop growing and spreading without causing them to shrink in size.

What are cytostatic drugs used for?

The term cytostatic denotes an aggressive toxic substance, which is used for medical treatments. Cytostatic drugs slow down or stop the growth of specific cells by inhibiting their cell division.

What is the difference between cytotoxic and cytostatic?

Cytotoxic agents are drugs that result in cell kill and eventual tumour shrinkage, whereas cytostatic agents inhibit tumour growth without direct cytotoxicity. Molecularly targeted agents may be cytostatic or cytotoxic.

What is cytotoxic drug action?

Cytotoxic refers to a substance or process which results in cell damage or cell death. The prefix "cyto" refers to cell and "toxic" to poison. The term is often used to describe chemotherapy drugs that kill cancer cells, but it may also be used to describe toxins, such as venom.

Pharmacology - Chemotherapy agents (MOA, Alkalating, antimetabolites, topoisomerase, antimitotic )

41 related questions found

What happens if you touch a cytotoxic drug?

Exposure to cytotoxic drugs has been reported to cause increased frequency of chromosome damage in exposed workers. They can cause acute skin, eye, and mucous membrane irritations, as well as nausea, headaches, and dizziness.

Why cytotoxic drugs are hazardous?

Cytotoxic drugs are intended primarily for the treatment of cancer. They are known to be highly toxic to cells, principally through their action on cell reproduction. ... Workers who come into contact with cytotoxic drugs and related waste are also at risk of exposure and possible adverse effects.

Is cytostatic hazardous?

Cytotoxic and Cytostatic drugs are classified as hazardous substances as defined by the Control of Substances Hazardous to Health Regulations 2002 (COSHH) and as hazardous waste by the Hazardous Waste Regulations.

What are the names of cytotoxic drugs?

Related drugs
  • ALLOPURINOL.
  • APREPITANT.
  • AZATHIOPRINE.
  • BLEOMYCIN.
  • CARMUSTINE.
  • CISPLATIN.
  • CYCLOPHOSPHAMIDE.
  • DACARBAZINE.

Why use cytotoxic precautions?

Cytotoxic precautions are used to make sure that other people do not come in contact with your cancer treatment or body fluids. Although the risk is very low, it is important to be careful. These precautions are needed when handling your cancer treatment or body fluids.

Is Methotrexate a cytotoxic drug?

Methotrexate is a folic acid antagonist and is classified as an antimetabolite cytotoxic agent.

What is methotrexate used for?

Methotrexate is a type of medicine called an immunosuppressant. It slows down your body's immune system and helps reduce inflammation. It is used to treat inflammatory conditions, including: rheumatoid arthritis.

What is antineoplastic material?

Antineoplastic drugs are medications used to treat cancer. Antineoplastic drugs are also called anticancer, chemotherapy, chemo, cytotoxic, or hazardous drugs. These drugs come in many forms. Some are liquids that are injected into the patient and some are pills that patients take.

What is cytotoxic and cytostatic waste?

Cytotoxic and cytostatic waste includes medicines in tablet, liquid, cream or aerosol form. Cytotoxic and cytostatic medicines are medicines that are either: toxic, carcinogenic, mutagenic or toxic for reproduction. They include: most hormonal preparations. some anti-viral drugs.

What are antimetabolite drugs?

Antimetabolites are a class of anticancer drugs defined as compounds, structurally similar to natural purine or pyrimidine base, nucleoside or nucleotides, molecules needed to carry out primary metabolic reactions that by virtue of their similarity act as analogues of a normal metabolites, interfere with the normal ...

What does apoptosis mean in biology?

Listen to pronunciation. (A-pop-TOH-sis) A type of cell death in which a series of molecular steps in a cell lead to its death. This is one method the body uses to get rid of unneeded or abnormal cells.

What are the 5 types of diuretics?

Thiazides are the most commonly prescribed diuretics. They're most often used to treat high blood pressure. These drugs not only decrease fluids, they also cause your blood vessels to relax.
...
Thiazide diuretics
  • chlorthalidone.
  • hydrochlorothiazide (Microzide)
  • metolazone.
  • indapamide.

Is azathioprine a cytotoxic drugs?

Cyclophosphamide, azathioprine, chlorambucil, and methotrexate are cytotoxic drugs used most commonly for the purpose of immunosuppression.

Why is methotrexate cytotoxic?

Methotrexate exerts its chemotherapeutic effect by being able to counteract and compete with folic acid in cancer cells resulting in folic acid deficiency in the cells and causing their death.

What medicines are hazardous?

The only medicinal products that are automatically deemed to be hazardous are cytotoxic and cytostatic medicines.

Is Methotrexate a hazardous drug?

Methotrexate can pose a health hazard to caregivers. All caregivers should take safety precautions while giving this drug. For 48 hours after this drug is given, the patient's body fluids can contain the drug.

What is clinical waste?

Clinical waste is the term used to describe waste produced from healthcare and similar activities that may pose a risk of infection, for example, swabs, bandages, dressings etc. or may prove hazardous, for example medicines. The most commonly used definition can be found in the Controlled Waste Regulations 1992 .

How should cytotoxic drugs be stored?

Cytotoxic medications should be stored in a hard-walled and robust container, securely closed and labelled with cytotoxic warnings. Refrigeration may be necessary.

Is it safe to kiss someone on chemo?

Kissing is a wonderful way to maintain closeness with those you love and is usually okay. However, during chemotherapy and for a short time afterward, avoid open-mouth kissing where saliva is exchanged because your saliva may contain chemotherapy drugs.

Are cytotoxic drugs specific?

They are extensively used to treat cancer, as they kill tumour cells by interfering with cell division. However, their actions are not specific to tumour cells and normal cells may also be damaged. This means potentially serious side-effects in both patients or others exposed.