Where does immune thrombocytopenic purpura occur?

Last Update: April 20, 2022

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Asked by: Mariela Dickens
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ITP occurs when certain immune system cells produce antibodies against platelets. Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels. The antibodies attach to the platelets. The body destroys the platelets that carry the antibodies.

How does ITP occur?

Immune thrombocytopenia usually happens when your immune system mistakenly attacks and destroys platelets, which are cell fragments that help blood clot. In adults, this may be triggered by infection with HIV , hepatitis or H. pylori — the type of bacteria that causes stomach ulcers.

How does immune thrombocytopenic purpura affect the body?

Immune thrombocytopenic purpura (ITP) is a blood disorder characterized by a decrease in the number of platelets in the blood. Platelets are cells in the blood that help stop bleeding. A decrease in platelets can cause easy bruising, bleeding gums, and internal bleeding.

What does ITP spots look like?

One of the most common symptoms of ITP is a skin condition called petechiae. These are small red bumps on your skin caused by bleeding from underneath. Petechiae can look like a red rash at first, but the bumps are slightly raised, scattered, and the size of pinpoints. They can also have a purplish tinge.

Is immune thrombocytopenic purpura more common in males or females?

Overall, the disease prevalence was higher in women than men, but the prevalence of childhood ITP was higher in males than females. The prevalence of initial symptoms including petechiae, purpura and ecchymosis was 60.5% and 61%, respectively in all patients, but severe bleeding rarely occurred in patients (28.8%).

Immune Thrombocytopenia (ITP) | Most COMPREHENSIVE Explanation

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Can ITP turn into leukemia?

ITP does not turn into a more serious blood disorder, like leukemia or aplastic anemia. It is usually not a sign that their child will later develop other autoimmune conditions, such as systemic lupus erythematosus (SLE or “lupus”).

Does ITP weaken immune system?

A: The specific cause of ITP is unknown, but it is known that ITP causes the body's immune system to destroy healthy platelets that can lead to easy or excessive bruising or bleeding.

What is the best treatment for ITP?

Corticosteroids have been used as a first-line treatment for ITP for more than 30 years, according to available research from 2016. They can be given orally or intravenously. Two corticosteroids that may be prescribed for ITP are high-dose dexamethasone and oral prednisone (Rayos).

What is the life expectancy of someone with ITP?

Predicted 5-year mortality rates ranged from 2.2% for patients younger than 40 years to 47.8% for those older than 60 years. A 30-year-old woman remaining thrombocytopenic due to ITP was predicted to lose 20.4 years (14.9 quality-adjusted life years) of her potential life expectancy.

Can ITP go away on its own?

The disease goes away by itself within two to six months. chronic ITP – this ongoing form accounts for most ITP seen in adults and is far less common in children. Chronic ITP has similar symptoms to acute ITP, except that it lingers for longer than six months.

Is immune thrombocytopenic purpura life-threatening?

For most children and adults, ITP isn't a serious or life-threatening condition. Acute ITP in children often goes away on its own within a few weeks or months and doesn't return. In 80 percent of children who have ITP, the platelet count returns to normal within 6 to 12 months. Treatment may not be needed.

What disease destroys platelets?

Immune thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting. People with the disease have too few platelets in the blood.

Can you recover from thrombocytopenia?

Most children recover without treatment within 6 weeks. If your thrombocytopenia is drug induced, your physician may change your prescription. Most people recover without additional treatment after they stop taking the medication.

Who is at risk for thrombocytopenia?

People who are at highest risk for thrombocytopenia are those affected by one of the conditions or factors discussed in "What Causes Thrombocytopenia?" This includes people who: Have certain types of cancer, aplastic anemia, or autoimmune diseases. Are exposed to certain toxic chemicals.

How can I live with ITP?

Living with ITP
  1. Improve Fatigue. Many people with ITP and other autoimmune diseases feel tired much of the time. ...
  2. Stop Bleeding. ...
  3. Take Care of Your Caregiver. ...
  4. Wear Medical Alert Jewelry. ...
  5. Cope with Corticosteroids. ...
  6. Laughter is the Best Medicine. ...
  7. References.

Can ITP be caused by stress?

Research suggests that physical or psychological stress and the resultant oxidative stress in the body may also trigger episodes of ITP,7 exacerbate fatigue15 and prolong duration of the platelet disorder in children.

Can you live a long life with ITP?

For most adults with ITP, the condition is chronic (lifelong). The variety of symptoms in ITP is affected by your platelet count. The lower your platelet count is, the more likely you are to have spontaneous and unexpected bleeding, both internally and externally.

Does ITP get worse with age?

The incidence of ITP increases with age and is more common over the age of 60. Among adults (age 30-60) diagnosed with chronic ITP, there are 2.6 cases among women for every case involving a male. In older adults, about the same number of men and women are diagnosed with ITP.

What should you avoid with ITP?

The Association recommends plenty of fruits and vegetables, whole grain bread and other starches, lower-fat dairy, lean meat, fish, eggs, beans, nuts, and seeds. They also recommend avoiding foods high in fat and sugar.

How is ITP diagnosed?

Diagnostic Procedures for ITP

Includes a special blood test called an "anti-platelet antibody test." Careful review of medications. Bone marrow aspiration: This test examines the platelet production and can rule out any abnormal cells the marrow may be producing that could lower platelet counts.

Is ITP a serious disease?

In the majority of people with ITP, the condition isn't serious or life-threatening. Acute ITP in children often resolves within six months or less without treatment. Chronic ITP can last for many years. People can live for many decades with the disease, even those with severe cases.

Do low platelets affect your immune system?

Summary: Platelets play a much bigger role in our immune system than previously thought, according to researchers. In addition to their role in coagulation and healing, platelets also act as the immune system's first responders when a virus, bacterium, or allergen enters the bloodstream.

What cancers cause ITP?

Immune Thrombocytopenic Purpura (ITP) is in rare cases secondary to solid tumors, particularly breast cancer. In these cases, the clinical course of the ITP may follow the clinical course of the primary tumor, and remission of the ITP may be induced by treatment of the primary tumor.

What is the difference between ITP and leukemia?

While acute leukaemia is known to be an aggressive disease that usually presents with features of bone marrow failure, presence of excess of blasts in the bone marrow, spillage of blasts into the peripheral circulation and evidence of multiple tissue infiltration;1,7 ITP is known to be associated with an abnormal ...

Is ITP cancerous?

Immune thrombocytopenia (ITP) is associated with an increased risk of hematologic malignancies, but data on the risk of developing solid tumors are either mixed, as with stomach and liver cancers, or largely unavailable.