Which diuretic causes gynecomastia?

Last Update: April 20, 2022

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Asked by: Josianne Bauch
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Furosemide, a loop diuretic

loop diuretic
Loop diuretics are medications used in the management and treatment of fluid overload conditions such as heart failure, nephrotic syndrome or cirrhosis, and hypertension, in addition to edema.
https://www.ncbi.nlm.nih.gov › books › NBK546656
, also indicated in congestive heart failure, is also reported to cause gynecomastia.

Which drugs can cause gynecomastia?

Medications probably associated with gynecomastia include risperidone, verapamil, nifedipine, omeprazole, alkylating agents, HIV medications (efavirenz), anabolic steroids, alcohol and opioids.

Why do potassium sparing diuretics cause gynecomastia?

Spironolactone can cause gynecomastia (enlargement of glandular tissue in the male breast) due to effects on estrogen steroid receptors. Due to its greater selectivity for mineralocorticoid receptors, eplerenone has not been associated with this side effect.

How does spironolactone cause gynecomastia?

Spironolactone induces gynecomastia by decreasing testosterone production, increasing peripheral conversion of testosterone to estradiol, and displacing estradiol from sex hormone-binding globulin. Generally, discontinuation of treatment results in resolution of gynecomastia.

Can hydrochlorothiazide cause gynecomastia?

The development of gynecomastia appears to be related to both dosage level and duration of therapy and is normally reversible when Spironolactone and Hydrochlorothiazide is discontinued. In rare instances, some breast enlargement may persist when Spironolactone and Hydrochlorothiazide is discontinued.

What Causes Gynecomastia

43 related questions found

Does Flomax cause gynecomastia?

Gynaecomastia is among the recognized adverse effects experienced by patients treated with finasteride and dutasteride, whereas no cases have been associated to tamsulosin. No information on gynecomastia related to tamsulosin in the literature. Gynaecomastia is not mentioned in the SPC of tamsulosin.

Is spironolactone a thiazide diuretic?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Which diuretic can cause breast enlargement?

Furosemide, a loop diuretic, also indicated in congestive heart failure, is also reported to cause gynecomastia. [3] Hence, chances of gynecomastia could be enhanced if these two drugs are coadministered.

Why does spironolactone cause breast enlargement?

Breast changes

Spironolactone frequently causes breast pain and breast enlargement in women. This is "probably because of estrogenic effects on target tissue." At low doses, breast tenderness has been reported in only 5% of women, but at high doses, it has been reported in up to 40% of women.

What is the most common cause of gynecomastia?

Gynecomastia is often due to an imbalance of testosterone and estrogen hormones. Certain medications and diseases can also cause male breast tissue to swell and get bigger. Enlarged breasts in boys and men often improve without treatment.

Does potassium cause gynecomastia?

Moreover gynecomastia is rare after potassium canrenoate or canrenone (4, 5), while 30–62% of patients on long term spironolactone experience this side-effect (4, 7). However, these studies were retrospective and were in patients with arterial hypertension or heart failure or in normal males.

Which is a potassium sparing diuretics?

Examples of potassium-sparing diuretics include: Amiloride (Midamor) Eplerenone (Inspra) Spironolactone (Aldactone, Carospir)

What is a thiazide diuretic drug?

Thiazide diuretics are drugs that cause both natriuresis (removal of sodium in the urine) and diuresis. Thiazide diuretics work by blocking sodium and chloride (Na/Cl) channels in the distal convoluted tubule of the nephron and inhibit the reabsorption of sodium and water.

What medication causes male breast growth?

Anti-androgen Medications

Some common examples include flutamide, finasteride (Proscar, Propecia) and spironolactone (Aldactone). These drugs inhibit androgen synthesis or activity, which disrupts the balance between male and female hormones in the body. This can potentially result in male breast enlargement.

What type of diuretic is eplerenone?

Synopsis: Eplerenone, a potassium-sparing diuretic similar to spironolactone, selectively blocks aldosterone to lower blood pressure. However, its safety profile is improved over spironolactone because of reduced progesterone and androgen-receptor effects.

Does increasing testosterone reduce gynecomastia?

Any man with gynecomastia is highly unlikely to have excess testosterone, since high testosterone causes insulin sensitivity that prevents fat deposits building within breast tissue and helps increase a man's lean mass.

How long does gynecomastia last after spironolactone?

Discontinuing use of spironolactone (Aldactone) often results in regression of breast tissue within three months. Routine testicular ultrasonography should be considered in men with gynecomastia to detect nonpalpable testicular tumors that were missed on clinical examination.

How long does it take for spironolactone to cause gynecomastia?

Gynecomastia risk then increases of 1-2% for treated patients. Spironolactone, an aldosterone antagonist used for high blood pressure treatment, presents both anti-androgenic and oestrogenic activities. This drug can induce gynecomastia after one month only of treatment, with a dose-dependent incidence.

Does spironolactone increase breast size?

Breast growth from spironolactone is usually small and reversible. But in some people, the breast tissue remains even after the spironolactone is stopped. Estrogen causes permanent nipple development and breast growth.

Does amiodarone cause gynecomastia?

Angiotensin-converting enzyme inhibitors, spironolactone, digoxin, amiodarone, verapamil, diltiazem, and nifedipine are the medications commonly used in Cardiology practice and they are all reported to be the cause of gynecomastia.

Which diuretic has the highest risk of causing breast enlargement in men?

Changes in blood sugar levels are also possible. Skin reactions, some severe, are possible with thiazide diuretics (such as hydrochlorothiazide). Potassium-sparing diuretics, such as spironolactone (Aldactone) may cause breast enlargement in males.

Does famotidine cause gynecomastia?

The most common side effect is headache. Cimetidine. Side effects are rare. But diarrhea, dizziness, rashes, headaches, and gynecomastia may occur.

Which is better hydrochlorothiazide or spironolactone?

Spironolactone is superior to hydrochlorothiazide for blood pressure control and arterial stiffness improvement.

Who should not take spironolactone?

a condition where the adrenal glands produce less hormones called Addison's disease. low amount of sodium in the blood. high levels of potassium in the blood. acute kidney failure.

Does spironolactone have sulfa in it?

Diuretics that do not contain a sulfonamide group (eg, amilodde hydrochloride, eplerenone, ethacrynic acid, spironolactone, and triamterene) are safe for patients with an allergy to sulfa.