Who guidelines for treatment of tuberculous meningitis?

Last Update: April 20, 2022

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The WHO guidelines recommend a first-line regimen of 2 months of isoniazid, rifampicin, pyrazinamide, and ethambutol (children) or streptomycin (adults) followed by 10 months of isoniazid and rifampicin.

WHO TB meningitis treatment guidelines?

Antimicrobials. Current WHO guidelines for TBM are based on those developed to treat PTB and suggest treatment with 2 months of rifampicin (RMP), isoniazid (INH), pyrazinamide (PZE) and ethambutol (ETB) followed by up to 10 months of RMP and INH for all patients [7].

What is the treatment of tuberculous meningitis?

The best antimicrobial agents in the treatment of TBM include isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and streptomycin (SM), all of which enter cerebrospinal fluid (CSF) readily in the presence of meningeal inflammation. Ethambutol is less effective in meningeal disease unless used in high doses.

WHO guideline for tuberculosis 2020?

There are 18 recommendations in the 2020 update. The main changes include conditional recommendations for a 1 month daily rifapentine and isoniazid regimen, and a 4 month daily rifampicin regimen as alternative treatment options.

WHO TB treatment duration?

Regimens for treating TB disease have an intensive phase of 2 months, followed by a continuation phase of either 4 or 7 months (total of 6 to 9 months for treatment). This is the preferred regimen for patients with newly diagnosed pulmonary TB.

Management of tuberculous meningitis:An update- Dr. Guy Thwaites

22 related questions found

WHO recommended grouping of anti-TB drugs?

The WHO group 5 drug classification refers to anti-TB drugs with unclear efficacy or an unclear role in MDR-TB treatment (9). These include thiacetazone, linezolid, high-dose isoniazid, clofazimine, amoxicillin with clavulanate, macrolides, carbapenem, and thioridazine.

What is ATT treatment?

Efficacy and safety of modified anti-tubercular treatment(ATT) regimens in treatment of tuberculosis(TB) in patients with underlying chronic liver disease(CLD)

Who controls tuberculosis control?

The following measures can be taken to reduce the risk for exposure: Implementing a respiratory protection program; Training health care personnel on respiratory protection; and. Educating patients on respiratory hygiene and the importance of cough etiquette procedures.

WHO TB publishing?

Key publications
  • Tuberculosis in the WHO European Region: factsheet (2021) ...
  • Tuberculosis elimination in the WHO European Region (2020) ...
  • Review on palliative care with focus on 18 high tuberculosis priority countries, 2020. ...
  • Quick guide to video-supported treatment of tuberculosis (2020)

How can TB meningitis be prevented?

Prevention. The best way to prevent TB meningitis is to prevent TB infections. In communities where TB is common, the Bacillus Calmette-Guérin (BCG) vaccine can help control the spread of the disease. This vaccine is effective for controlling TB infections in young children.

How long is a child with TB meningitis treated?

Treatment should include isoniazid, rifampin, pyrazinamide, and either ethambutol or streptomycin. Total treatment should extend for 12 months.

How is TBM diagnosed?

To diagnose TBM, the CT scan is done in a special way. Images are collected when you breathe in and then again when you breathe out. This lets the CT scan see if your airways are collapsing when you exhale.

What is TBM medical?

Overview. Tracheobronchomalacia (TBM) is a rare condition that occurs when the tissue that makes up the windpipe, or trachea, is soft and weak. A healthy windpipe, or trachea, is stiff. It remains open while you breathe or cough.

Who isoniazid preventive therapy guidelines?

The usual preventive therapy regimen is isoniazid (10 mg/kg daily for children, up to a maximum adult dose of 300 mg daily). The recommended duration of isoniazid preventive treatment varies from 6 to 12 months of continuous therapy (9).

How do u get TB meningitis?

How TB meningitis is caused. Tuberculosis bacteria enter the body by droplet inhalation i.e. breathing in bacteria from the coughing/sneezing of an infected person.

Who end TB strategy?

The World Health Organization (WHO) End TB Strategy aims to end the global TB epidemic by 2035, reducing global TB incidence and mortality rates by 90% and 95%, respectively, in 2035 when compared to 2015 (WHO, 2014; Uplekar et al., 2015; Lönnroth et al., 2015).

WHO TB epidemiology?

The average prevalence of all forms of tuberculosis in India is estimated to be 5.05 per thousand, prevalence of smear-positive cases 2.27 per thousand and average annual incidence of smear-positive cases at 84 per 1,00,000 annually. The credibility and use of the estimates are discussed in detail.

What program was implemented by the WHO to Stop TB?

The Stop TB Strategy, launched on World TB Day in 2006, is designed to meet the TB-related Millennium Development Goal (MDG) as well as the Stop TB Partnership targets set for 2015. The Stop TB Strategy underpins the Global Plan to Stop TB 2006–2015.

WHO TB criteria?

WHO criteria employs simple clinical features and chest X-ray (Table 1). These include prolonged duration of cough and/or fever, failure to thrive or severe malnutrition, result of TST, suggestive physical findings, and a positive chest X-ray (Table 1).

How is tuberculosis controlled?

Environmental controls include technologies for the removal or inactivation of airborne M. tuberculosis. These technologies include natural ventilation, local exhaust ventilation, general ventilation, HEPA filtration, and ultraviolet germicidal irradiation (UVGI).

What are the recommended CDC guidelines for preventing the transmission of tuberculosis in health care settings?

Specific actions to reduce the risk of tuberculosis transmission should include a) screening patients for active tuberculosis and tuberculous infection, b) providing rapid diagnostic services, c) prescribing appropriate curative and preventive therapy, d) maintaining physical measures to reduce microbial contamination ...

Why is TB treated with 4 drugs?

When two or more drugs to which in vitro susceptibility has been demonstrated are given together, each helps prevent the emergence of tubercle bacilli resistant to the others. The standard of care for initiating treatment of TB disease is four-drug therapy.

WHO recommended TB treatment?

The standardized regimens for anti-TB treatment recommended by WHO include five essential medicines designated as “first line”: isoniazid (H), rifampicin (R), pyrazinamide (Z), ethambutol (E) and streptomycin (S). Table 2.1 shows the recommended doses for adults and children.